What are the limitations of eGFR?

What are the limitations of eGFR?

The main limitation of eGFR formulas. The main limitation of the eGFR formulas is significant lack of accuracy in individuals as compared to groups. This causes problems in establishing the presence or absence of early CKD.

What are the limitations of creatinine clearance?

One of the major limitations of creatinine clearance testing is that it becomes less accurate as the GFR declines because of increasing tubular secretion of creatinine. This results in the GFR being overestimated. Sex and race can alter creatinine clearance.

What does the Cockcroft and Gault equation measure?

The Cockcroft-Gault formula for estimating creatinine clearance (CrCl) should be used routinely as a simple means to provide a reliable approximation of residual renal function in all patients with CKD. CrCl (male) = ([140-age] × weight in kg)/(serum creatinine × 72) CrCl (female) = CrCl (male) × 0.85.

Can eGFR be inaccurate?

eGFR values derived from serum creatinine are frequently inaccurate when compared against GFR reference methods. The cause of this inaccuracy is likely related to non-functional factors, including unmeasured muscle mass and tubular secretion of creatinine. Accurate data are sparse.

Can eGFR be incorrect?

“Near the border of 60 mL/min/1.73 m2 creatinine-based eGFR can be inaccurate. More than half of patients with eGFR less than 60 have an eGFR of 45 to 60, and in that group there are a lot of false positives, meaning the eGFR based on creatinine says they have CKD, but their kidney function may be normal.

What is modified Cockcroft Gault?

A modified Cockcroft-Gault formula taking into account the body surface area gives a more accurate estimation of the glomerular filtration rate. J Nephrol.

What are the limitations of the Cockcroft and Gault equation?

To circumvent these limitations, several equations have been developed to estimate GFR from the serum creatinine concentration adjusted for age, sex, body weight and demographic factors [ 1 ]. The equation proposed by Cockcroft and Gault in 1976 is widely used throughout the world [ 2, 3 ].

What are the limitations of Cockcroft-Gault and MDRD?

Limitations of Cockcroft-Gault and MDRD formulas in estimating GFR among top-level rugby players The MDRD formula underestimates the CrCl in rugby players, even when corrected for BSA. Conversely, the CG formula more closely approximates the actual CrCl measurement.

How to calculate GFR using the Cockcroft-Gault study?

BSA was calculated as (Weight in kg × Height in cm/3,600) 1/2. CG was normalized per 1.73 m 2. Albuminuria was defined as urine albumin excretion rate >30 mg/d or urinary albumin-creatinine ratio >30 mg/g. CER was estimated using the CG equation (which is an estimation of CCr) for each patient, as (140 − age) × body weight/72 (×0.85 if female).

When did Cockcroft and Gault formula come out?

The Cockcroft and Gault formula (CG) was developed in 1973 using data from 249 men with creatinine clearance (CCr) from approximately 30 to 130 mL/m2. It is not adjusted for body surface area.