Which test is most specific for infectious mononucleosis?

Tests for antibodies to Epstein-Barr viral capsid antigen or Epstein-Barr nuclear antigen are the most sensitive, are highly specific, and are also the most expensive for diagnosing infectious mononucleosis (strength of recommendation [SOR]: C, based on validating cohort study).

What test is diagnostic for infectious mononucleosis?

The monospot test is done to help diagnose a recent mono infection. Epstein-Barr virus (EBV) antibody testing is also done to help diagnose mono. The EBV antibody test can help determine whether you have ever been infected with the virus and whether the infection has been recent.

What is EBV serology blood test?

The EBV test is also known as “EBV antibodies.” It’s a blood test used to identify an EBV infection. The test detects the presence of antibodies. Antibodies are proteins that your body’s immune system releases in response to a harmful substance called an antigen.

Can mono trigger celiac disease?

The virus that causes mononucleosis might also increase the risk for celiac disease and six other autoimmune conditions, a new study suggests. Epstein-Barr is a common virus that causes “mono,” a condition marked by extreme fatigue, sore throat, body aches and swollen lymph nodes.

How accurate is the test for mono?

The mono test is 71% to 90% accurate and may be used as an initial test for diagnosing infectious mononucleosis. However, the test does have a 25% false-negative rate due to the fact that some people infected with EBV do not produce the heterophile antibodies that the mono test is designed to detect.

What is a positive Monospot test?

A positive test means heterophile antibodies are present. These are most often a sign of mononucleosis. Your provider will also consider other blood test results and your symptoms. A small number of people with mononucleosis may never have a positive test.

Can I go to work with mono?

People can return to school, college, or work once they are feeling better, and their doctor approves. Some people may still feel tired for several weeks or months after other symptoms go away, which may affect their work. Mono can cause an enlarged spleen.

What viral infection causes celiac disease?

Infection with reovirus, a common but otherwise harmless virus, can trigger the immune system response to gluten that leads to celiac disease, according to new research.

Can Epstein Barr cause celiac?

Relationship Found Between Autoimmune Disease and Epstein-Barr Virus. A new study suggests a protein produced by the Epstein-Barr virus can increase the risk of developing celiac disease and six other autoimmune diseases.

How are genetic tests used to diagnose celiac disease?

(3) A definitive diagnosis of celiac disease requires a jejunal biopsy demonstrating villous atrophy. (1-3) Given the invasive nature and cost of the biopsy, serologic and genetic laboratory tests may be used to identify individuals with a high probability of having celiac disease.

Do you need a biopsy for celiac disease?

However, just as with the IgA-deamidated gliadin antibody, a biopsy should be performed to confirm the diagnosis. Negative deamidated gliadin IgA and/or IgG antibody serology does not exclude a diagnosis of celiac disease, as antibody levels decrease over time in patients who have been following a gluten-free diet.

Can a person with celiac disease have a negative antibody test?

IgA deficiency in a patient may be indicative of other diseases that may cause villus atrophy, such as giardiasis, small-bowel bacterial overgrowth (SIBO) or common variable immunodeficiency (CVID). 2 While it is very rare, it is possible for someone with celiac disease to have negative antibody test results.

When do clinical findings of infectious mononucleosis occur?

The clinical findings of infectious mononucleosis occur in conjunction with the appearance of IgG and IgM anti-VCA antibodies. However, the antibody pattern is not stable before symptoms appear.