What drugs are metabolized by P450?

Among the drugs metabolized are sedatives such as midazolam, triazolam and diazepam, the antidepressives amitriptyline and imipramine, the anti-arryhthmics amiodarone, quinidine, propafenone and disopyramide, the antihistamines terfenadine, astemizole and loratidine, calcium channel antagonists such as diltiazem and …

What is a CYP2D6 inhibitor?

CYP2D6 Inhibitors Drugs that inhibit CYP2D6 activity are likely to increase the plasma concentrations of certain medications, and, in some cases, adverse outcomes will occur (see Table 3 below right for a list of known inhibitors).

Is CYP2D6 inherited?

Cytochrome P450 CYP2D6 is the most extensively characterized polymorphic drug-metabolizing enzyme. A deficiency of the CYP2D6 enzyme is inherited as an autosomal recessive trait; these subjects (7% of Caucasians, about 1% of Orientals) are classified as poor metabolizers.

What medicines should not be taken with grapefruit?

Examples of common medications that interact with grapefruit juice include certain statin cholesterol drugs such as atorvastatin (Lipitor), lovastatin, simvastatin (Zocor), felodipine (Plendil) and other calcium channel blockers, clarithromycin (Biaxin), and loratadine (Claritin).

Does grapefruit juice enhance Klonopin?

Clonazepam may be taken with food or on an empty stomach. Avoid drinking grapefruit juice while you are taking this medication as it can increase the levels of clonazepam in your blood.

What are the most common types of amphetamines?

List of Amphetamine Drugs. Amphetamines speed up the brain and are highly addictive central nervous system stimulants. The most common types of amphetamines are those legally prescribed to treat attention deficit disorder ADD, attention deficit hyperactivity disorder ADHD, narcolepsy, and obesity.

What are the side effects of taking amphetamines?

Amphetamines are stimulants that act on the central nervous system to produce the following effects shortly after being taken: 1 Altered sexual behavior. 2 Arrhythmias. 3 Cardiovascular failure. 4 Decreased appetite. 5 Decreased fatigue/drowsiness. 6 (more items)

What is the bioavailability of amphetamine in the body?

Pharmacokinetics. The oral bioavailability of amphetamine varies with gastrointestinal pH; it is well absorbed from the gut, and bioavailability is typically over 75% for dextroamphetamine. Amphetamine is a weak base with a pKa of 9.9; consequently, when the pH is basic, more of the drug is in its lipid soluble free base form,…

When did the use of amphetamines go down?

Once hailed as a wonder drug, amphetamine now ranks among the likes of morphine, cocaine and opium and while some decline was seen in its use, it never really went away. It continued to be produced illegally and another increase in its use was seen in the mid-1980’s.