What is NODAL gene?

What is NODAL gene?

Nodal is a secretory protein that in humans is encoded by the NODAL gene which is located on chromosome 10q22.1. In addition, Nodal seems to have important functions in neural patterning, stem cell maintenance and many other developmental processes, including left/right handedness.

Where is NODAL expressed?

2000; Hamada et al. 2002). In all cases, expression of the TGF-β signaling molecule, Nodal, is restricted to the left side of the embryonic axis, where its activity is critical for specifying the embryonic left-right (LR) axis.

What secretes NODAL?

NODAL is secreted from a structure called the node (shown in red) at the posterior side of the embryo.

Is NODAL a transcription factor?

Nodal thus modulates the transcription of a battery of genes. Among the proteins induced by Nodal is Nodal itself. Nodal upregulates Wnt3, which in turn maintains Nodal expression in the posterior part of the epiblast. Nodal also induces the expression of the Nodal inhibitors Cerberus and Lefty2 in the hypoblast.

What is a nodal city?

In region. Regions may be nodal, defined by the organization of activity about some central place (e.g., a town and its hinterland, or tributary area), or uniform, defined by the homogeneous distribution of some phenomena within it (e.g., a tropical rainforest).

What is nodal day?

The nodal period (or draconic period) of a satellite is the time interval between successive passages of the satellite through either of its orbital nodes, typically the ascending node.

Is nodal a BMP?

Nodal and BMP signal non-cell-autonomously and form similar protein gradients in this context, but the signaling range of Nodal (pSmad2) is shorter than the BMP range (pSmad5).

What is a nodal?

: being, relating to, or located at or near a node.

What is the salary of nodal officer?

Nodal Officer Salaries

What is the qualification for nodal officer?

MBA/Post graduation with minimum of 10 years experience in administration Preferably in health sector. Desirable: Knowledge and experience in Computer Applications. Age Limit: Not more than 55 yrs. For retired Govt.

Which are the nodal cities today?

The eighteenth century saw the rise of Bombay, Calcutta and Madras, which are nodal cities today.

What are the diseases associated with the nodal gene?

Diseases associated with NODAL include Heterotaxy, Visceral, 5, Autosomal and Visceral Heterotaxy . Among its related pathways are Mesodermal Commitment Pathway and Cardiac Progenitor Differentiation . Gene Ontology (GO) annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding .

Which is a paralog of the nodal protein gene?

Gene Ontology (GO) annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding . An important paralog of this gene is GDF6. Essential for mesoderm formation and axial patterning during embryonic development.

Are there any zebrafish that have a nodal gene?

Although mouse and human only have one nodal gene, the zebrafish contain three nodal paralogs: squint , cyclops and southpaw, and the frog five (xnr1,2,3,5 and 6).

What kind of receptors does the nodal bind?

Nodal can bind type I and type II Serine/Threonine kinase receptors, with Cripto-1 acting as its co-receptor. Signaling through SMAD 2/3 and subsequent translocation of SMAD 4 to the nucleus promotes the expression of genes involved in proliferation and differentiation.