What is the difference between myotonic dystrophy type 1 and type 2?
Myotonic dystrophy type 1 is caused by mutations in the DMPK gene, while type 2 results from mutations in the CNBP gene. The protein produced from the DMPK gene likely plays a role in communication within cells.
What is type 2 myotonic dystrophy?
Myotonic dystrophy type 2, one of the two types of myotonic dystrophy, is an inherited muscular dystrophy that affects the muscles and other body systems (e.g., heart, eyes, and pancreas). It is characterized by prolonged muscle tensing (myotonia) as well as muscle weakness, pain, and stiffness.
What is the difference between DM1 and DM2 myotonic dystrophy?
Congenital DM1 is characterized by muscle weakness (hypotonia), difficulty breathing, intellectual disability and early death. DM type 2 (DM2) causes similar symptoms to DM1, but is generally a less severe disorder and does not cause congenital disease. DM1 is caused by an alteration in the DMPK gene.
What is MMD disease?
Myotonic muscular dystrophy, also known as MMD or Steinert’s disease, is the most common form of MD in adults. It occurs in 1/30,000 people. It occurs in males and females, with symptoms typically beginning any time from early childhood through adulthood.
Can MMD be cured?
While there is no cure or treatment that slows progression of MMD, early intervention can reduce or eliminate some complications.
What is the life expectancy for someone with myotonic dystrophy?
Survival for 180 patients (from the register) with adult-onset type myotonic dystrophy was established by the Kaplan-Meier method. The median survival was 60 years for males and 59 years for females.
Which is more common MMD type 1 or 2?
Prognosis & Life Expectancy. The incidence rate is more in Type 1 than the type 2, it has been estimated that 1 in 8000 people suffer from MMD. The type 2 is more common in Finland and Germany.
When does myotonic muscular dystrophy ( mmd2 ) start?
MMD2, also called type 2: CNBP (ZNF9) is abnormal. This type begins later, usually between 30 and 60 years old. Doctors often group children with MMD1 based on the age when symptoms started.
What kind of disease is myotonic dystrophy type 2?
Myotonic dystrophy type 2, one of the two types of myotonic dystrophy, is an inherited muscular dystrophy that affects the muscles and other body systems (e.g., heart, eyes, and pancreas).
How to run the military movement drill ( MMD )?
Run quickly back to the starting line and plant the right foot, turn counterclockwise and touch the ground with the right hand. Run back to the 25-yard mark gradually accelerating to near maximum speed.