What causes succinate dehydrogenase deficiency?

In recent years, a defined set of genetic changes in these so-called wild-type GISTs have begun to be characterized, including activating mutations in BRAF,8, 9, 10 loss of function mutations in NF1,11 and mutations leading to loss of function of the succinate dehydrogenase (SDH) enzyme complex.

What is succinate dehydrogenase inhibited by?

Succinate dehydrogenase is also known as mitochondrial complex II, and inhibition of succinate dehydrogenase by dimethyl malonate has been reported to suppress the production of pro-inflammatory cytokines.

What is the metabolic function of succinate dehydrogenase?

Succinate dehydrogenase is a key enzyme in intermediary metabolism and aerobic energy production in living cells. This enzymes catalyses the oxidation of succinate into fumarate in the Krebs cycle (1), derived electrons being fed to the respiratory chain complex III to reduce oxygen and form water (2).

What happens if there is no succinate dehydrogenase?

A complete lack of succinate dehydrogenase activity will hamper electron flow to both respiratory chain complex III and the quinone pool, resulting in a major oxidative stress known to promote tumor formation in human.

Where is succinate dehydrogenase located?

inner mitochondrial membrane
Succinate Dehydrogenase is found in the inner mitochondrial membrane, but a portion lays in the mitochondrial matrix. As shown in the Jmol diagram, the red represents the hydrophobic regions of the enzyme.

What happens if succinate dehydrogenase is inhibited?

Where is succinate dehydrogenase located in prokaryotes?

EC no. CAS no. Succinate dehydrogenase (SDH) or succinate-coenzyme Q reductase (SQR) or respiratory complex II is an enzyme complex, found in many bacterial cells and in the inner mitochondrial membrane of eukaryotes.

What is succinate dehydrogenase a marker enzyme for?

Succinate dehydrogenase is a mitochondrial marker enzyme. It is one of the hub linking oxidative phosphorylation and electron transport. It can provide a variety of electron in respiratory chain for eukaryotic and prokaryotic cell mitochondria.