Is Trypanosoma cruzi curable?

Trypanosoma cruzi infection is curable if treatment is initiated soon after infection. In chronic patients, antiparasitic treatment can potentially prevent or curb disease progression and prevent transmission, for instance, mother-to-child infection.

How does Chagas disease cause achalasia?

Chagas disease is an infectious disease with esophageal functioning that mimics achalasia. This condition is caused by the protozoan T cruzi, which is transmitted by a reduviid (kissing) bug bite.

How is Chagas disease transmitted to humans?

When people become infected by the parasite Trypanosoma cruzi, they can get Chagas disease. The feces of insects called triatomine, or “kissing” bugs, transmits the parasite to humans. These bugs feed on the blood of animals and humans at night, and then they defecate.

What is the causative agent of Chagas disease?

The protozoan parasite, Trypanosoma cruzi, causes Chagas disease, a zoonotic disease that can be transmitted to humans by blood-sucking triatomine bugs.

What is the treatment for T cruzi?

The two drugs used to treat infection with T. cruzi are nifurtimox and benznidazole. Benznidazole is approved by FDA for use in children 2–12 years of age and is available from .

What are the symptoms of trypanosomiasis?

Fever, severe headaches, irritability, extreme fatigue, swollen lymph nodes, and aching muscles and joints are common symptoms of sleeping sickness. Some people develop a skin rash. Progressive confusion, personality changes, and other neurologic problems occur after infection has invaded the central nervous system.

Can MS cause achalasia?

Dysphagia has been estimated to occur in at least 33% of impaired MS patients and in 17% of MS patients with milder impairments. In addition, achalasia is rarely described in the setting of any central neurodegenerative disorder except for a few case reports of association with Parkinson’s disease.

What happens if your bit by a kissing bug?

Some people are allergic to kissing bug saliva. The skin near the bite might become red, swollen, and itchy. The most serious risk is anaphylactic shock. That’s when your blood pressure drops and you have trouble breathing.

How does infection with T. cruzi lead to heart disease?

T. cruzi induce production of the potent vasoconstrictor endothelin-1 from infected endothelial cells which may aggravate myocardial ischemia due to decreased circulatory capacity [23]. Another possibility is that microvascular damage may be indirectly initiated by the parasite, as it has been shown that T.

How long can you live with Chagas disease?

However, this symptom-free stage may only last about 10-20 years in some patients before the chronic symptoms develop in about 10%-30% of those infected. Some researchers compare the chronic phase of Chagas disease to HIV/AIDS.

How do you prevent T cruzi?


  1. Avoid sleeping in a mud, thatch or adobe house. These types of residences are more likely to harbor triatomine bugs.
  2. Use insecticide-soaked netting over your bed when sleeping in thatch, mud or adobe houses.
  3. Use insecticides to remove insects from your residence.
  4. Use insect repellent on exposed skin.

Which is the best description of the genus Trypanosoma?

Schizotrypanum Chagas 1909. Trypanozoon Lühe 1906. Trypanosoma is a genus of kinetoplastids (class Trypanosomatidae ), a monophyletic group of unicellular parasitic flagellate protozoa. Trypanosoma is part of the phylum Sarcomastigophora.

How many people are infected with Trypanosoma cruzi?

About 6 million to 7 million people worldwide, mostly in Latin America, are estimated to be infected with Trypanosoma cruzi, the parasite that causes Chagas disease. The main route of transmission to humans has occurred in Latin America through the insect called triatomine bug (vector-borne), which can carry the Trypanosoma cruzi.

Who are the parasites that cause African trypanosomiasis?

African Trypanosomiasis, also known as “sleeping sickness”, is caused by microscopic parasites of the species Trypanosoma brucei. It is transmitted by the tsetse fly ( Glossina species), which is found only in sub-Saharan Africa.

Who was the first person to discover Trypanosoma?

In 1903, David Bruce identified the protozoan parasite and the tsetse fly vector of African trypanosomiasis. The monophyly of the genus Trypanosoma is not supported by a number of different methods.