How long can a person live with smoldering myeloma?

How long can a person live with multiple myeloma?

Revised international staging system Median survival
Stage I 62 months (5 years, 2 months)
Stage II 42 months (3.5 years)
Stage III 29 months (2 years, 5 months)

What is high risk smoldering multiple myeloma?

Smoldering multiple myeloma (SMM) is an asymptomatic precursor state of multiple myeloma (MM). Recently, MM was redefined to include biomarkers predicting a high risk of progression from SMM, thus necessitating a redefinition of SMM and its risk stratification.

How do I know my smoldering in myeloma?

Smoldering myeloma patients should be observed and tested by their physician approximately every 3 months. Testing using blood tests, urine tests, bone marrow biopsy tests and imaging (PET-CT and MRIs) are all useful in the diagnosis of smoldering myeloma.

What is the meaning of smoldering myeloma?

Smoldering myeloma is a slow-growing type of multiple myeloma, a form of cancer in which abnormal plasma cells (purple) make too much of a single type of antibody.

Is smoldering multiple myeloma hereditary?

It may also run in some families. Age. This is a common risk factor for smoldering multiple myeloma. It often develops between 50 and 70.

What is the longest anyone has lived with multiple myeloma?

The longest follow up of a still alive patient with multiple myeloma is 31 years after detection of monoclonal protein and 25 years after beginning of antitumor treatment.

What is the standard of care for smoldering multiple myeloma?

The currently accepted definition of smoldering multiple myeloma requires a serum monoclonal protein level of 3 g per deciliter or more, 10% or more plasma cells in the bone marrow, or both in the absence of end-organ damage.

Which is a biomarker for high risk multiple myeloma?

A markedly elevated serum free light chain (FLC) ratio may serve as a biomarker for malignant transformation in high-risk smoldering multiple myeloma (SMM) and identify patients who are at imminent risk of progression. We retrospectively studied the predictive value of the serum (FLC) assay in 586 patients with SMM diagnosed between 1970 to 2010.

How many people have been smoldered by multiple myeloma?

During the 26-year period, 276 patients fulfilled the criteria for smoldering multiple myeloma. During 2131 cumulative person-years of follow-up, symptomatic multiple myeloma or amyloidosis developed in 163 persons (59%).

What is the clinical course and prognosis of multiple myeloma?

Clinical course and prognosis of smoldering (asymptomatic) multiple myeloma The risk of progression from smoldering multiple myeloma to symptomatic disease is related to the proportion of bone marrow plasma cells and the serum monoclonal protein level at diagnosis.