How do you administer IV imipenem?

Imipenem and cilastatin injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle). When imipenem and cilastatin is injected intravenously, it is usually infused (injected slowly) over a period of 20 minutes to 1 hour every 6 or 8 hours.

How do you dilute imipenem?

Each 500mg of dose should be diluted with 100ml of compatible IV fluid, whilst for a 1gm dose use a 250ml bag. Infuse doses of 500mg over 20 minutes. Infuse doses of 500mg to 1gm over 40 to 60 minutes. If patient develops nausea during infusion, the rate of infusion may be slowed.

How do you reconstitute imipenem and cilastatin?

Reconstitution and Dilution Reconstitute infusion bottles containing 250 mg of imipenem and 250 mg of cilastatin or 500 mg of imipenem and 500 mg of cilastatin with 100 mL of a compatible IV solution to provide solutions containing 2.5 or 5 mg/mL of each drug, respectively. Shake until a clear solution is obtained.

Why imipenem is given with cilastatin?

Because imipenem is rapidly inactivated by renal dehydropeptidase I (DHP-1), it is given in combination with cilastatin (sye” la stat’ in), a DHP-I inhibitor which increases half-life and tissue penetration of imipenem.

Is imipenem soluble in water?

Product Info

Cas No. 74431-23-5
Formula Wt. 317.36
Melting Point 106-111°C
Solubility Water 10 mg/ml, methanol 5 mg/ml, ethanol 0.2 mg/ml
Appearance White to off white powder

What is the difference between imipenem and meropenem?

Abstract Data synthesis: Imipenem, the first carbapenem, was first marketed in 1987; meropenem was introduced to the market in 1996. In general, imipenem is more active against Gram-positive cocci while meropenem is more active against Gram-negative bacilli. The agents display similar pharmacokinetics.

What is the action of imipenem?

Imipenem acts as an antimicrobial through the inhibition of cell wall synthesis of various gram-positive and gram-negative bacteria. This inhibition of cell wall synthesis in gram-negative bateria is attained by binding to penicillin-binding proteins (PBPs).

Can imipenem be given alone?

Imipenem is indicated for the treatment of severe infections due to multiresistant organisms. Alone, or in combination with an aminoglycoside, it can be used for serious mixed infections including pulmonary, intraabdominal, and soft-tissue infections. It is generally well tolerated.

What are the plasma levels of imipenem I.V.?

Intravenous infusion of PRIMAXIN I.V. over 20 minutes results in peak plasma levels of imipenem antimicrobial activity that range from 14 to 24 µg/mL for the 250 mg dose, from 21 to 58 µg/mL for the 500 mg dose, and from 41 to 83 µg/mL for the 1000 mg dose.

How long does it take for imipenem to work?

This medicine must be given slowly, and the infusion can take 20 to 60 minutes to complete. If you feel nauseated while injecting this medicine, you may need to give it more slowly. Imipenem and cilastatin is usually given as long as needed until your infection has cleared or you have been symptom-free…

Which is the sterile formulation of imipenem and cilastatin?

PRIMAXIN I.V. (Imipenem and Cilastatin for Injection) is a sterile formulation of imipenem (a thienamycin antibiotic) and cilastatin sodium (the inhibitor of the renal dipeptidase, dehydropeptidase l), with sodium bicarbonate added as a buffer.

What happens if you skip a dose of imipenem?

Skipping doses can increase your risk of infection that is resistant to medication. Imipenem and cilastatin will not treat a viral infection such as the flu or a common cold. Store unmixed medicine at room temperature, away from moisture and heat.