What is a PAF antagonist?

PAF antagonists do not provoke an inflammatory response upon binding, but block or lessen the effect of PAF. Examples of PAF antagonists are: CV-3988 is a PAF antagonist that blocks signaling events correlated to the expression and binding of PAF to the PAF Receptor.

What is PAF in blood?

Introduction. Platelet-activating factor (PAF) is a potent phospholipid mediator that was first described by its ability to cause platelet aggregation and dilation of blood vessels. Now it is also known as a potent mediator of inflammation, allergic responses, and shock.

Is PAF vasoconstrictor or vasodilator?

We found that in the isolated microperfused rabbit afferent arteriole, PAF has a bi- phasic effect, inducing vasodilation at very low concentrations and vasoconstriction at higher concentrations. Both of these effects appear to be receptor mediated, since they were blocked by a specific PAF receptor antagonist.

What is the importance of platelet-activating factor?

Platelet-activating factor is a potent lipid mediator of inflammation that has immunomodulatory effects and a pivotal role in the pathogenesis of inflammatory disorders and cardiovascular disease.

Do platelets cause vasodilation?

Platelet-activating factor (PAF, 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a potent mediator of inflammation that causes neutrophil activation, increased vascular permeability, vasodilation, and bronchoconstriction in addition to platelet activation.

Is Platelet Activating Factor a cytokine?

Abstract. Platelet-activating factor (PAF), a lipid that acts as a potent proinflammatory mediator, is involved in several reproductive processes including parturition. The PAF-induced cytokine production was abolished by co-incubation with WEB 2170, a specific PAF receptor antagonist.

How do platelets activate?

Platelets are normally activated in the presence of tissue injury with endothelial disruption and loss of activation inhibitors, exposure of the von Willebrand factor that binds it’s receptor and slows circulating platelets, and release of ADP, thrombin, and TxA2 as well as binding of fibrinogen or collagen to αIIb/β3.

Does PAF cause vasodilation?

At picomolar concentrations (lower than those that caused constriction), PAF produced dose-dependent vasodilation that was unaffected by cyclooxygenase inhibition but was abolished by EDNO synthesis inhibition. Both PAF-induced constriction and dilation of Af-Arts were blocked by a PAF receptor antagonist.

Is Platelet-Activating Factor a mediator?

Platelet-activating factor (PAF) is a phospholipid with potent, diverse physiological actions, particularly as a mediator of inflammation.

What are the side effects of PAF antagonists?

The main complication of PAF is the induction of inflammation [34], which further leads to different ailments related to cardiac [35], renal, and central nervous system [36] and peripheral, digestive systems [37]. The PAF antagonists stops all these unwanted reactions and diseases in our body.

Which is an antagonist of platelet activating factor ( PAF )?

Phytochemical formulas having PAF antagonistic property. PAF and other pro-inflammatory agents such as 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates the NF-κB and IκB complex present in the cytoplasm and hence phosphorylated IκB is formed and which after its degradation gets converted to active NF-κB.

What are some diseases that are caused by PAF?

Since it is assumed that PAF play a central role in etiology of many diseases in humans such as asthma, neuronal damage, migraine, cardiac diseases, inflammatory, headache etc..

How does PAF play a role in inflammation?

PAF play a significant role in inflammation, which further initiates different unwanted effects. At the time of inflammation the exemplary via leukocytes migrates through endothelial barrier and rolling, activation and adhesion occurs, by which ultimately leukocyte recruitment occurs.