What are thymic stromal lymphocytes?
Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine expressed in skin, gut, lungs, and thymus.
What does the gene TSLP do?
TSLP synergized with CD40 ligand to promote dendritic cell activation and pathogenic IL-23 production by primary blood and skin dendritic cells. It plays an important role as a master switch of allergic inflammation because it promotes Th2-type immune responses by inducing the activation of dendritic cells.
What cells produce TSLP?
TSLP has been reported to be expressed by a range of cell types, including epithelial cells, fibroblasts, keratinocytes, IgE receptor-activated mast cells, protease-activated basophils, and human CD68+ macrophages, whereas it was not observed to be produced by other lympho-hematopoietic cells, including neutrophils, B …
Where is TSLP produced?
TSLP is produced predominantly by airways and nasal epithelial cells and by skin keratinocytes and also stimulates immature myeloid dendritic cells, which express the heterodimeric TSLP receptor to differentiate into mature dendritic cells.
What is TSLP in asthma?
Abstract. Thymic stromal lymphopoietin (TSLP) is an allarmin cytokine whose importance in human asthma has been repeatedly documented. Accordingly, targeting of TSLP and TSLP-mediated signalling is considered as an attractive therapeutic strategy to asthma.
Is TSLP a cytokine?
Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine produced by epithelial cells, keratinocytes, fibroblasts, and stromal cells in the context of infection and inflammation.
What is TSLP inflammation?
Thymic stromal lymphopoietin (TSLP) is a critical upstream cytokine inducing type 2 inflammation in various diseases, including asthma and atopic dermatitis.
What is the purpose of stromal cells?
Stromal cells are connective tissue cells of any organ, and they support the function of the parenchymal cells of that particular organ.
Is Tslp a cytokine?
How do you treat Tslp?
TSLP has been implicated in asthma pathophysiology. Tezepelumab is a first-in-class human monoclonal antibody that binds to TSLP, thus inhibiting its interaction with TSLP receptor complex. Tezepelumab given as an add-on-therapy to patients with severe uncontrolled asthma has shown safety, tolerability and efficacy.
How does the thymic stromal lymphopoietin receptor work?
Within the thymus TSLP activation of both myeloid and plasmacytoid (CD123+) dendritic cells results in the production of regulatory T cells. TSLP signals through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor CRLF2 and the IL-7R alpha chain.
How is the thymic stromal lymphopoietin receptor heterocomplex in pediatric asthma?
Expression and Regulation of Thymic Stromal Lymphopoietin and Thymic Stromal Lymphopoietin Receptor Heterocomplex in the Innate-Adaptive Immunity of Pediatric Asthma
Where are TSLP and IL-7Rα expressed in cells?
TSLP is an IL-7-like cytokine expressed by epithelial cells and keratinocytes. Its receptor comprises TSLPR and IL-7Rα, which is expressed primarily on monocytes and myeloid-derived DCs, as well as on B cells.
Which is part of the TSLP receptor complex?
TSLP signals through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor CRLF2 and the IL-7R alpha chain. After binding STAT5 phosphorylation is induced resulting in the expression of upstream transcription factors.