Is imidazole a good leaving group?
imidazole is a better leaving group, contrary to what we would expected. k2 (n-C4HgNH2) .
What is a good leaving group?
Good leaving groups are weak bases. They’re happy and stable on their own. Some examples of weak bases: halide ions (I-, Br-, Cl-) water (OH2), and sulfonates such as p-toluenesulfonate (OTs) and methanesulfonate (OMs). The weaker the base, the better the leaving group.
Which is better leaving group Cl or H?
Typically the leaving group is an anion (e.g. Cl-) or a neutral molecule (e.g. H2O). The better the leaving group, the more likely it is to depart. A “good” leaving group can be recognised as being the conjugate base of a strong acid.
What is imidazole antifungal?
Among the azole group of antifungal medications, imidazoles (miconazole and ketoconazole) are commonly used for localized surface infections and triazoles (itraconazole—for dermatophytes only—fluconazole, voriconazole, and posaconazole) are used for invasive, life-threatening fungal infections.
What does imidazole treat?
An imidazole antifungal used to treat vulvovaginal candidiasis. A broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections. A topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor.
Which is not imidazole antifungal drug?
Types of antifungal Of the clinically employed azole antifungals, only a handful are used systemically. These include ketoconazole, itraconazole, fluconazole, fosfluconazole, voriconazole, posaconazole, and isavuconazole. Examples of non-azole systemic antifungals include griseofulvin and terbinafine.
What is the mechanism of the Van Leusen imidazole synthesis?
Mechanism of the Van Leusen Imidazole Synthesis. The mechanism according to a publication by Van Leusen (J. Org. Chem., 1977, 42, 1153-1159. Abstract) is driven by TosMIC, which contains a reactive isocyanide carbon, an active methylene group and a leaving group.
Which is the mild protocol for making imidazoles?
The mild protocol tolerates a broad range of aliphatic and aromatic substrates, and offers an efficient access to highly diverse, multisubstituted imidazoles in very good isolated yields. A. Angyal, A. Demjén, J. Wölfling, L. G. Puskás, I. Kanizsai, J. Org. Chem., 2020, 85, 3587-3595.
How are imidazoles produced in an electrochemical cyclization?
An efficient electrochemical oxidative tandem cyclization of aryl ketones and benzylamines provides 1,2,4-trisubstituted- (1 H )-imidazoles in very good yields under metal- and oxidant-free conditions. This direct C-N bond formation strategy offers a broad functional group tolerance.
How is an aldimine produced from an imidazole?
Elimination of p -toluenesulfinic acid (TosH) from the intermediate 4-tosyl-2-imidazoline provides a 1,5-disubstituted imidazole:: The aldimine can also be generated in situ by condensation of an amine with an aldehyde in approximately half an hour.