How do you reconstitute benzathine penicillin injection?
Reconstitution of the suspension for intramuscular injection: The suspension must be prepared aseptically. The contents of the vial should be reconstituted in at least 2ml (0.6 Million I.U.), 3.5ml (1.2 Million I.U.), or 5ml (2.4 Million I.U.) of diluent (e.g. water for injections which is included in the pack).
How do you reconstitute penicillin G?
Reconstitution. Intermittent IV infusion: 5 million unit vial: Add 8.2 mL SWFI or NS for a final concentration of 500,000 units/mL; add 3.2 mL for a final concentration of 1,000,000 units/mL. Dilute further to 50,000 to 145,000 units/mL prior to infusion.
How do you mix benzylpenicillin IV?
For intravenous infusion, dilute with Glucose 5% or Sodium Chloride 0.9%; give over 15–30 minutes. Longer administration time is particularly important when using doses of 50 mg/kg (or greater) to avoid CNS toxicity.
Can benzylpenicillin be given IV?
Intramuscular, intravenous. Only freshly prepared solutions should be used. Reconstituted solutions of benzylpenicillin sodium are intended for immediate administration.
Can crystalline penicillin treat syphilis?
Treating tertiary syphilis For neurosyphilis or affliction of the nerves and brain 3 to 4 million units IV of Aqueous Crystalline Penicillin G every 4 hours for 10-14 days (18-24 million units/day) is given.
How many milligrams of benzylpenicillin are in a vial?
Benzylpenicillin benzathine 1.2 Million I.U. powder and solvent for suspension for injection 2. Qualitative and quantitative composition 1 vial of powder for suspension for injection contains 1.2 Million I.U., equivalent to approximately 918 mg benzylpenicillin benzathine, or approximately 720 mg benzylpenicillin.
How many mg of benzathine benzylpenicillin in one buttock?
– For a 2.4 MIU (1.8 g) dose, administer 1.2 MIU (900 mg) in each buttock. – Do not confuse long-acting benzathine benzylpenicillin, for IM injection, with rapidly acting benzylpenicillin (or penicillin G), administered by Iv route. – Do not mix with other drugs in the same syringe.
How much Benzathine is in a penicillin injectable?
BENZATHINE BENZYLPENICILLIN injectable 1 Therapeutic action 2 Indications 3 Forms and strengths, route of administration 4 Dosage 5 Duration 6 Contra-indications, adverse effects, precautions. – Do not administer to penicillin-allergic patients. 7 Remarks. – For a 2.4 MIU (1.8 g) dose, administer 1.2 MIU (900 mg) in each buttock.
What is the mechanism of action for benzylpenicillin benzathine?
Mechanism of action. For benzylpenicillin benzathine, the mechanism of action is based on an inhibition of bacterial cell wall synthesis (during the growth phase) through a blockade of the penicillin-binding proteins (PBPs), such as transpeptidases. This results in a bactericidal action. Resistance