What are the contraindications of nitroglycerin sublingual?

Nitroglycerin is contraindicated in patients who are allergic to it. Sublingual nitroglycerin therapy is contraindicated in patients with early myocardial infarction, severe anemia, increased intracranial pressure, and those with a known hypersensitivity to nitroglycerin.

What are contraindications for nitroglycerin?

Nitroglycerin is contraindicated in patients that have reported allergic symptoms to the medication. [18] Known history of increased intracranial pressure, severe anemia, right-sided myocardial infarction, or hypersensitivity to nitroglycerin are contraindications to nitroglycerin therapy.

What are the 5 contraindications of nitroglycerin?

Contraindications of nitroglycerin

Have a known sensitivity to nitrate medications.
Have taken erectile dysfunction medications within the past 24 hours, such as Viagra, Cialis, Levitra, Stendra, Staxyn, sildenafil, avanafil, tadalafil or vardenafil.
Are hypotensive (typically <90 SBP or <65 MAP)

What are complications of nitroglycerin?

Side Effects Headache, dizziness, lightheadedness, nausea, and flushing may occur as your body adjusts to this medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Headache is often a sign that this medication is working.

Why is nitroglycerin taken sublingually?

Glyceryl trinitrate (or nitroglycerin) undergoes extensive hepatic presystemic metabolism when given orally, and is therefore usually given by the sublingual route, by which it is well absorbed and rapidly taken up into the circulation.

What is the function of the sublingual nitroglycerin?

NITROGLYCERIN (nye troe GLI ser in) is a type of vasodilator. It relaxes blood vessels, increasing the blood and oxygen supply to your heart. This medicine is used to relieve chest pain caused by angina.

What is the mechanism of action of nitroglycerin?

Mechanism of Action: Nitroglycerin forms free radical nitric oxide (NO) which activates guanylate cyclase, resulting in an increase of guanosine 3’5′ monophosphate (cyclic GMP) in smooth muscle and other tissues.

What are the actions of nitroglycerin on the human body?

Nitroglycerin works by relaxing the smooth muscle and blood vessels in your body. This increases the amount of blood and oxygen that reaches your heart. In turn, your heart doesn’t work as hard. This reduces chest pain.

How much does nitroglycerin lower BP?

At 5 and 10 min after sublingual nitroglycerin, mean reduction of mean arterial blood pressure by 12.3 and 16.3% was achieved. Only 2 patients (5.4%) showed an overcorrection of blood pressure.

What happens if you take nitroglycerin?

Taking nitroglycerin when not needed can lead to severe headaches for one. It also could lead to an unsafe drop in blood pressure and can cause tachycardia which is a rapid heart rate, palpitations and fainting.

Does Nitro lower heart rate?

Nitro sublinguals instantly open whole body vascular system. For FIVE minutes. Period. It is only potent for 5 minutes….during which time heart rate is lower and blood takes more time to recirculate back into the heart chambers.

When to take Nitro pill?

The nitroglycerin tablet (Nitrostat ®) is a prescription medication used to treat sudden episodes of chest pain (angina). It can also be used just before physical activity, such as exercise or sexual intercourse, to help prevent anticipated chest pain.