What is gastric metaplasia in duodenum?
Gastric metaplasia is a term used to describe the presence of gastric-type mucus-secreting cells in the surface epithe- lium of the duodenum. The disorder is largely restricted to the duodenal bulb and involves the replacement of normal absorptive and goblet cells by gastric foveolar epithelium.
What causes ulcers in the duodenal bulb?
Most ulcers are caused by an infection from a bacteria or germ called H. pylori. This bacteria hurts the mucus that protects the lining of your stomach and the first part of your small intestine (the duodenum). Stomach acid then gets through to the lining.
What is the most reliable symptom of duodenal ulcer?
Symptoms of a duodenal ulcer have pain in the stomach or abdomen (this might come and go and is relieved by eating or taking an antacid) have indigestion. feel very full and bloated after eating. feel like you might vomit (nauseous)
What is duodenal bulb deformity?
CONCLUSION: There is a correlation among deformity of duodenal bulb, gastric metaplasia of duodenal regenerating mucosa and recurrence of duodenal ulcer. A more severely deformed duodenal bulb is closely related to a greater extent of gastric metaplasia. Both factors contribute to the recurrence of duodenal ulcer.
Does intestinal metaplasia go away?
In the long term, with follow up of at least five years, there is epidemiological evidence that IM may be reversible although a combination of antioxidant agents and eradication of H pylori may be necessary to achieve this.
What is the treatment for a duodenal ulcer?
A duodenal ulcer is usually caused by an infection with a germ (bacterium) called Helicobacter pylori (H. pylori). A 4- to 8-week course of acid-suppressing medication will allow the ulcer to heal. In addition, a one-week course of two antibiotics plus an acid-suppressing medicine will usually clear the H.
What is the purpose of duodenal bulb?
The first segment of the duodenum—the superior part of the duodenum (called the duodenal bulb) is connected to the liver via the hepatoduodenal ligament. This connection allows for transportation of nutrients from the small intestine to the liver; it also allows the duodenum to receive bile from the liver.
What does a normal duodenal bulb look like?
The duodenal bulb is well distended, with its normal triangular shape. Another image from an upper GI series demonstrates the normal smooth mucosal surface of the duodenal bulb, as opposed to the normal feathery fold pattern of the remaining duodenum and jejunum.
Should I worry about intestinal metaplasia?
Perhaps the biggest concern for those with intestinal metaplasia is that it might be precancerous. The abnormal cells in the digestive tract may go through a stage called dysplasia if left untreated. These abnormal cells may or may not progress to cancerous cells.
Why does a duodenum ulcer cause gastric metaplasia?
Gastric metaplasia, which develops in response to an increased duodenal acid load, allows colonization of H. pylori to occur in the duodenum. Colonization of H. pylori in the metaplastic gastric tissue induces further metaplasia because of bacteria-activated inflammation, duodenitis, and ulceration.
Is there a correlation between duodenal ulcer and deformity?
There is a correlation among deformity of duodenal bulb, gastric metaplasia of duodenal regenerating mucosa and recurrence of duodenal ulcer. A more severely deformed duodenal bulb is closely related to a greater extent of gastric metaplasia. Both factors contribute to the recurrence of duodenal ulcer.
Is there chronic inflammation in the duodenal bulb?
Overall, 235 (19%) had gastric metaplasia and/or chronic inflammation in the duodenal bulb mucosa, and H. pylori organisms could be found in 17 (1%).
Where does an ulcer occur in the duodenum?
Duodenal ulcers usually occur at the duodenal cap, where the acidic chyme meets the duodenal mucosa, before it mixes with the alkaline secretions of the duodenum. The duodenum does not have the same protective mechanisms as the stomach mucosa.