How do you calculate cisplatin?
The actually utilized dose (AD) of cisplatin was calculated using the following formula: AD (mg) = total dose (TD) (mg)-losing dose (LD) (mg); LD = volume (ml) of the perfusate (VPretained) that was retained in the HIPEC treatment system at the end of HIPEC * concentration of cisplatin in the perfusate (mg/ml).
How do you mix cisplatin?
The cisplatin solution for infusion prepared according to instructions (see section 6.6.) should be administered by intravenous infusion over a period of 6 to 8 hours. mixture of sodium chloride solution 0.9% and glucose solution 5% (1:1). Cisplatin 1 mg/ml sterile concentrate is to be diluted before administration.
Which IV fluid is used to dilute inj cisplatin?
All Patients The drug is then diluted in 2 liters of 5% Dextrose in 1/2 or 1/3 normal saline containing 37.5 g of mannitol, and infused over a 6 hour to 8 hour period. If diluted solution is not to be used within 6 hours, protect solution from light. Do not dilute cisplatin in just 5% Dextrose Injection.
What is the strength of cisplatin injection?
Each vial of Cisplatin for injection, USP contains 50 mg Cisplatin, 450 mg Sodium Chloride, USP, and 500 mg Mannitol, USP.
How much Cisplatin is in a 50 ml injection?
Cisplatin Injection is a clear, colorless to pale yellow, sterile aqueous solution. Each 50 mL or 100 mL amber vial of Cisplatin Injection contains: 1 mg/mL cisplatin, 9 mg/mL sodium chloride, hydrochloric acid and/or sodium hydroxide to adjust pH, and water for injection to a final volume of 50 mL or 100 mL, respectively.
How often should I take cisplatin for monotherapy?
For monotherapy, the following two dosage regimens are recommended: Single dose of 50 to 120 mg/m 2 body surface every 3 to 4 weeks; If cisplatin is used in combination therapy, the dose of cisplatin must be reduced. A typical dose is 20mg/m 2 or more once every 3 to 4 weeks.
When to take cisplatin in combination with gemcitabine?
For the treatment of malignant mesothelioma in combination with gemcitabine†. Cisplatin 100 mg/m2 IV on day 1 in combination with gemcitabine 1000 mg/m2 IV on days 1, 8 and 15, every 28 days for 6 cycles.
What are the most common side effects of cisplatin?
The most common side effects of Cisplatin include: Tell the doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Cisplatin. For more information, ask your doctor or pharmacist.